The 49ers played their home games at Jerry Richardson Stadium in Charlotte, North Carolina, and compete in their first season as a member of the American Athletic Conference (AAC).

[2][3] On December 2 Saint Frances Academy defensive line coach Wayne Dorsey took the same position for the 49ers.

[5][6] On December 3 it was revealed that Buffalo defensive backs coach Rod Ojong would be accepting the same position at Charlotte.

[9] On the same date LSU graduate assistant and former Notre Dame team captain Greer Martini was named linebackers coach.

[13] On January 16 longtime Poggi friend and business associate Jonathon Jacobson was named assistant head coach and senior advisor.