[8][9][10][11] Kiptum broke free from all the other runners by the 35 km (22 mi) mark, and finished the race with a significant negative split.

[18] Swiss wheelchair athletes Marcel Hug and Catherine Debrunner both set course records with their victories, finishing with times of 1:22:37 and 1:38:44, respectively.

[37][38][39][d] Benson Kipruto of Kenya, who won the previous year's race with a time of 2:04:24, returned to defend his title.

[45][46][43][44][e] Belgian runner Bashir Abdi, who won the bronze medal at the men's marathon event of the 2020 Olympics, also made an appearance.

[51][49][44] Swiss wheelchair athlete Marcel Hug, the previous year's champion, returned to defend his title.

[52][53] Daniel Romanchuk and Aaron Pike of the United States, and Sho Watanabe of Japan, who placed second, third, and fourth in 2022, respectively, all returned for the race.

[52][54] Susannah Scaroni of the United States returned to defend her title, with her compatriot Tatyana McFadden who sought to secure her tenth Chicago Marathon victory, and Manuela Schär of Switzerland who aimed to earn her third.

[46][15][11][g] Kiptum, Mateiko, and Kirui passed the 10 km (6.2 mi) mark in world record pace with a time of 28:42.

[46][56][57] Kiptum and Mateiko had fallen slightly behind world record pace when they crossed the halfway mark at 1:00:48.

[13] Defending champion Benson Kipruto was over three minutes behind, finishing the race in second place with a personal best time of 2:04:02.

[58] Defending champion Ruth Chepng'etich set a quick pace early on with Sifan Hassan, who was running her second marathon.

[18] Together, they reached the 10 km (6.2 mi) mark in 31:05, forty seconds faster than Tigst Assefa did when she set the world record in Berlin two weeks earlier.

[18][11] Defending champion Marcel Hug did not really face any competition during the race, breaking away from the other athletes right from the start.

[53][57] The race ended up being essentially a time trial for Hug, and he broke the course record, which he had set himself the previous year, by almost three minutes.

[54][57] The two leading women, defending champion Susannah Scaroni and world record holder Catherine Debrunner, were dueling throughout the race, with the lead switching between the two until Debrunner grabbed it in the final mile and broke off from Scaroni when turning into Columbus Drive for the final stretch.