On August 10, 2021, incumbent premier Brian Pallister announced that he would not seek re-election and resigned shortly after.

Stefanson primarily campaigned on reducing the cost of living for Manitobans, crime, and parental rights in education.

The PCs promoted the film industry in the province and in 2022 helped WestJet launch direct flights from Los Angeles to Winnipeg.

[14] During the final stages of the campaign, a point of contention was the proposed search of a Winnipeg landfill for the remains of the murdered Indigenous women Morgan Harris and Marcedes Myran.

[20] In the final days of the campaign, the Manitoba government reported a surplus in the provincial budget worth $270 million.

[42] Liberal leader Dougald Lamont resigned on election night following a dismal performance for his party.

Both he and Jon Gerrard lost their seats to NDP challengers, leaving Cindy Lamoureux as the sole Liberal in the legislative assembly.