The Wolverines, wee led by head coach Bonnie Tholl in her first season, and played their home games at Alumni Field in Ann Arbor, Michigan.

Following the conclusion of the regular season, the Wolverines received an at-large bid to the 2022 NCAA Division I Softball Tournament and were defeated in the Regional Final by UCF.

[4] On July 5, 2022, Michigan added three transfer students, outfielder Ellie Mataya and pitchers Hannah George and Jessica LeBeau.

At the time of her retirement, she was the winningest coach in NCAA Division I history with a record of 1,707–555–5.

During her career as head coach, Michigan never suffered a losing season, and she led the team to 22 Big Ten regular-season titles from 1995–2021, including nine in a row from 2008–16, 10 Big Ten Tournament championships, and qualified for the NCAA Tournament 29 times, including each of the last 27 years.