They started 10–45 in their first 55 games, which tied them with the 1904 Washington Senators and 1899 Cleveland Spiders for the worst 55-game start in MLB history and with a 21–60 first half, were on pace to tie (and at some points in the season, break) the record for most losses in a season in the modern era set by the 1962 Mets before having a 29–52 second half to avoid breaking the record.

[1] With their loss on August 8, the Athletics became the fastest team to be guaranteed a losing season since the 2003 Detroit Tigers, who lost 82 of their first 111 games.

Although the Athletics showed signs of improvement in the second half of the season, they still became the first team since the 2019 Detroit Tigers to lose 111 or more games, en route to finishing 50–112.

The A's finished last or close to last in the American League and in MLB in most batting and pitching categories this season.

[2] On November 7, 2022, the Athletics announced that bench coach Brad Ausmus would not return for the 2023 season.