The fixture for the season was announced on 11 January 2023, with the competition starting on 10 February and ending on 10 December 2023.
The bottom-placed team at the end of the regular season was relegated to the Segunda División Profesional.
[5] The tournament was played by 16 teams, 13 returning from the previous season, two relegated from the 2022 Campeonato Nacional (Deportes La Serena and Deportes Antofagasta), and the 2022 Segunda División Profesional champions San Marcos de Arica.
The winning side claimed the last promotion spot to the Campeonato Nacional for the next season.
Tied 4–4 on aggregate, Deportes Iquique won on penalties and promoted to the Chilean Primera División.