The 2023 San Luis Open Challenger was a professional tennis tournament played on outdoor clay courts.

It was the 28th edition of the tournament for the men which is part of the 2023 ATP Challenger Tour[1] and 1st edition for the women which is part of the 2023 WTA 125 tournaments.

[2] It took place at the Club Deportivo Potosino in San Luis Potosí, Mexico between 27 March and 9 April 2023.

The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following pair received a wildcard into the doubles main draw: