The 2023 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts.

It was the 54th edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP Tour 250 Series of the 2023 ATP Tour.

It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 21 to August 27, 2023.

[2] The following players received wildcard entry into the singles main draw: The following players received entry as alternates: The following players received entry from the qualifying draw: The following players received entry as lucky losers: † Rankings are as of 14 August 2023.

The following pairs received wildcard entry into the doubles main draw : The following pairs received entry as alternates: