The 2024–25 AFC Challenge League knockout stage will be played from 5 March to 10 May 2025.
[1] A total of 8 teams will compete in the knockout stage to decide the champions of the 2024–25 AFC Challenge League.
Extra time and penalty shoot-out will be used to decide the winners if necessary (note that the away goals rule is abolished).
[1] In the quarter-finals, the eight qualified teams play in two ties, with the matchups and order of legs determined by the group stage draw and the identity of the best runners-up in the West region.
In the Semi-finals, the winners of quarter-finals from each region will face each other in two leg matches.