[5] On 17 May, Blackpool announced their first four pre-season matches, against AFC Fylde, Sunderland, Tranmere Rovers and Crewe Alexandra.

[6] Two new signings occurred in June, to become official on 1 July: Jordan Rhodes,[7] who was on loan at the club the previous season, joined on a free transfer, as did fellow striker Ashley Fletcher.

A week later, Blackpool played Cádiz CF as part of the club's training stint in Spain.

Forward Zak Emmerson joined FC Halifax Town on a permanent transfer on 23 July.

Two more defeats followed—at Tranmere and at home to Accrington Stanley—before pre-season was brought to a close with a 2–0 victory at Neil Critchley's former club, Crewe Alexandra.

Three days later, Elliot Embleton, previously on loan at Blackpool, was signed on a permanent basis on a two-year contract.

[11] Win Draw Loss Fixtures Blackpool began their League One campaign with a 2–1 defeat at Crawley Town on 10 August.

[12] Three days later, Blackpool reached the second round of the EFL Cup with a 4–0 victory at Burton Albion.

Ryan Finnigan (on his debut), Matthew Pennington (2) and Lee Evans (first for the club) got the goals, each in the second half.

After three years at Bloomfield Road, goalkeeper Daniel Grimshaw joined Plymouth Argyle for an undisclosed fee on 23 August.

Three days later, Blackpool reached the third round of the EFL Cup, after a 2–1 victory over Blackburn Rovers at Ewood Park.

[17] On 30 August, transfer deadline day, forward Kylian Kouassi joined League Two Salford City on loan until the end of the season.

[18] Right-back Odeluga Offiah arrived at Bloomfield Road on loan from Brighton for the rest of the season.

[19] On 3 September, Blackpool beat Crewe Alexandra 4–1 at Bloomfield Road in the group stage of the EFL Trophy, maintaining Richard Keogh's unbeaten start as interim manager.

[21] Blackpool beat Exeter City 2–1 at Bloomfield Road on 14 September, after a 94th-minute winner by James Husband, in Steve Bruce's first game in charge.

Sheffield Wednesday, with a single-goal victory, knocked Blackpool out of the EFL Cup at the third-round stage on 17 September.

CJ Hamilton doubled their advantage five minutes into first-half injury time, netting his fourth goal of the season.

[26] Steve Bruce won the EFL League One Manager of the Month award for September off the back of the wins.

[27] Blackpool made it seven league games unbeaten on 1 October with a 1–1 draw with Lincoln City at Bloomfield Road.

[29] This was followed, two weeks later, by a 2–1 home defeat to Barnsley; Oliver Casey got Blackpool's goal, an equaliser, but the visitors scored the winner in injury time.

[34] Blackpool's winless streak stretched to six league games on 9 November, after a 3–0 defeat to Leyton Orient at Brisbane Road.

[37] A victory followed at Bristol Rovers on 26 November, with goals by Dom Ballard and Lee Evans (penalty).

[38] On 1 December, Blackpool exited the FA Cup after a second-round defeat to Birmingham City at Bloomfield Road.

[39] Ten days later, Blackpool made it three consecutive league victories after taking all three points at Reading, with goals from Albie Morgan, Ashley Fletcher and Rob Apter.

On 18 January, after a two-week break due to a postponement, Blackpool drew for a fourth-consecutive match, this time at home to Huddersfield Town.

Blackpool went two goals up, through Rob Apter and Albie Morgan, but the visitors scored twice early in the second half.

[47] Blackpool made it nine draws in their last twelve games with a 3–3 scoreline at home to Mansfield Town on 15 February.

The hosts' goals came from Sonny Carey, Ashley Fletcher (his sixth of the campaign) and Niall Ennis.