[4] League A maintains the same format introduced for the 2023–24 season, consisting of a group stage, a quarter-finals round and the finals.

[3] The quarter-finals will be played on a two-legged home-and-away basis, with the four winners advancing to the Nations League Finals and qualifying directly to the 2025 CONCACAF Gold Cup.

[5] League A teams will qualify for the 2025 CONCACAF Gold Cup final tournament or the Gold Cup qualification tournament (also called CONCACAF Gold Cup prelims) or advance to the play-in round based on their performance in the group stage and quarter-finals round, as follows:[4] A total of sixteen national teams contest the League A, including the top twelve sides from the 2023–24 season and four promoted from the 2023–24 League B.

The top four ranked teams (Mexico, the United States, Panama and Canada) were directly seeded in the quarter-finals.

[4] The match-ups were as follows: Each tie was played on a home-and-away two-legged basis, with the order of legs being decided by the four pre-seeded teams that received a direct bye to the quarter-finals (Canada, Mexico, Panama and the United States).

[42] Panama won 3–2 on aggregate, advanced to the Finals and qualified for the 2025 CONCACAF Gold Cup.

The United States won 5–2 on aggregate, advanced to the Finals and qualified for the 2025 CONCACAF Gold Cup.

The four teams were ranked based on their results in the two quarter-finals legs to determine the semi-final matchups.