Each tie is played on a home-and-away two-legged basis, with the teams from League A hosting the second legs.
[4] If the aggregate score is level at the end of the second leg the away goals rule would be applied.
Teams were seeded based on their results during the group stage of their respective league, in order to determine the pairings.
[5] Guadeloupe won 7–0 on aggregate and qualifies for the 2025 CONCACAF Gold Cup qualification.
Guyana won 9–4 on aggregate and qualifies for the 2025 CONCACAF Gold Cup qualification.