The 2024–25 Colorado Buffaloes women's basketball team represents the University of Colorado Boulder during the 2024–25 NCAA Division I women's basketball season.

The Buffaloes are by ninth year head coach JR Payne and play their home games at the CU Events Center.

This season is Colorado's first season as members of the Big 12 Conference since 2011 after they rejoined the conference in August 2024.

They defeated Oregon in the First Round of the Pac-12 women's tournament before losing to Oregon State in the quarterfinals.

[2][3] Colorado received an at-large bid to the NCAA Women's Tournament where they defeated Drake in the First Round and Kansas State in the Second Round before losing to Iowa in the Sweet Sixteen.