The 2024–25 Columbia Lions women's basketball team represented Columbia University during the 2024–25 NCAA Division I women's basketball season.

The Lions, led by ninth-year head coach Megan Griffith, play their home games at Levien Gymnasium in New York City as members of the Ivy League.

They finished the previous season 23–7, 13–1 in Ivy League play, winning a share of the Ivy League title with Princeton.

They defeated Harvard in the 2024 Ivy League women's basketball tournament semifinals before losing to Princeton in the championship game.

They received an at-large bid to the NCAA women's tournament for the first time in school history.