Athletic Bilbao were the defending champions, having beaten Mallorca in the final of the previous edition, but were eliminated in the round of 16 by Osasuna.
In the summer of 2024, the RFEF released the calendar of the competition and confirmed the format of the previous season would remain.
[22] The first round was played by 110 of the 115 qualified teams, with the exceptions being the four participants of the 2025 Supercopa de España, and the Primera RFEF champions.
[23] The second round was played by 56 teams, with the four participants of the 2025 Supercopa de España having a bye.
The Primera RFEF champion, Deportivo La Coruña, entered in this round.
[34] The draw for the round of 32 was held on 9 December 2024 in the RFEF headquarters in Las Rozas.
The draw for the round of 16 was held on 8 January 2025 in the RFEF headquarters in Las Rozas.
The draw for the quarter-finals was held on 20 January 2025 in the RFEF headquarters in Las Rozas.
The draw for the semi-finals was held on 12 February 2025, in the RFEF headquarters in Las Rozas.