The 2024–25 DePaul Blue Demons men's basketball team represents DePaul University during the 2024–25 NCAA Division I men's basketball season.

They are led by first-year head coach Chris Holtmann.

They play their home games at Wintrust Arena in Chicago, Illinois, as members of the Big East Conference.

They lost to Villanova in the first round of the Big East tournament.

On January 22, 2024, the school fired head coach Tony Stubblefield after starting the season 3–15.