The 2024–25 DePaul Blue Demons women's basketball team represents DePaul University during the 2024–25 NCAA Division I women's basketball season.

The Blue Demons are led by thirty-ninth year head coach Doug Bruno and play their home games at the Wintrust Arena as members of the Big East Conference.

The Blue Demons finished the season 12–20, 4–14 in Big East play to finish in tenth place.

10 seed, they lost in the first round to Seton Hall of the Big East women's tournament.

Roster Source:[1] *The preseason and week 1 polls were the same.