[12] The previous season ended later than usual, during the summer international window, with the final 2023–24 Liga F game on 16 June 2024.

[18] Mariona Caldentey confirmed her departure from the club at the start of June,[19] while Ariana Arias and Bartel did so towards the end of the month,[20][21] when it was also announced that Lucy Bronze would not renew her contract.

Pajor scored her first hat-trick with the club and Alexia Putellas converted two penalties, with a variety of other players also getting on the scoresheet, including a Granada own goal.

Barcelona also saw one goal, a header from the edge of the box by Keira Walsh, dubiously ruled out due to Putellas being apparently offside earlier in the play.

Ahead of the match, defender Marta Torrejón – one of the goalscorers, for her 70th Barcelona goal – was given a recognition award to mark her twentieth year of elite football.

Walsh and Fridolina Rolfö both made their 50th overall Champions League appearances, and a record attendance of 5,508 was set at Manchester's Joie Stadium.

In a match of two halves, Manchester City pressed high to pose the stronger threat in the first half, scoring off a corner.

Barcelona were the stronger side in the second half but their attempts to equalise did not come to fruition and City added a second goal towards the end of the match.

[50] Barcelona again had a concerning first half when they returned to league action on 20 October before the international break; they achieved a 4–1 victory over Levante, including Nazareth's first official goal for the team and an improved defense but less clinical attack.

[52] After the club won Women's Club of the Year at the 2024 Ballon d'Or ceremony on 28 October, and Aitana Bonmatí followed Putellas to win a second consecutive Ballon d'Or Féminin,[53] these trophies were presented to the home crowd at the first match in November, at home against Eibar.

St. Pölten continued with a strong defensive performance to shut out Barcelona until the 87th minute, when Graham Hansen scored to make it 7–0.

[62] Besides the strong team performance, UEFA highlighted individuals, saying that Walsh and Batlle both could have been player of the match as well as the honoree Pina.

Controlling possession, Barcelona called it "a question of time" for them to score, which came in the form of a brace for Nazareth[67] soon followed by Vicky López's first Champions League goal.

[76] The latter included six players who represented Barcelona during 2024, with Bronze, Irene Paredes, Batlle, Guijarro, Bonmatí, Graham Hansen and Paralluelo featured.

Though Levante midfielder Ainhoa Bascuñán was sent off shortly afterwards, Barcelona could not equalise in the remaining extra length of overtime; the match went over 100 minutes.

Romeu said after the match that he had not thought he would need to make substitutions, with the game compared to those earlier in the season when Barcelona mounted large comebacks after not scoring in the first half; when Levante went ahead, he instead changed the attack wholesale and introduced progressive centre-back Mapi León.

[81][80] Still, Romeu said that "under normal circumstances", the team he put out would have won the game, instead criticising Levante for time-wasting and other disruptive play, though he acknowledged such tactics are commonly used against Barcelona in the Liga F.[82][83] He also reflected that Walsh's departure, and rumours of Engen also leaving, were distractions, but he did not think this affected the team.