Barcelona will play their official home matches at the Estadi Olímpic Lluís Companys until 23 April 2025, when it is expected to return to the Camp Nou still under-renovation works and with no full seating capacity available.

[13][14] On 9 August, Barcelona announced reaching an agreement to sign Dani Olmo from RB Leipzig for a reported fee of €60 million on six-year contract, therefore the Spaniard completed a return move to his youth career club.

[17][18] On 24 August, the team defeated Athletic Bilbao 2–1 in their first home match of the season, with Lewandowski and Yamal scoring a goal each.

[28] Barcelona started the Champions League campaign with a 2–1 defeat at the hands of Monaco, after Eric García got sent off early on in the first half.

[29] Yamal scored the only goal for the team and his first in the Champions League and became the second youngest goalscorer of all time in the competition, only behind his teammate Ansu Fati who holds the record.

[35] Barcelona's perfect start of seven straight wins in La Liga ended after they suffered their first league defeat of the season, losing 4–2 away to Osasuna.

[37] On 6 October, Barcelona defeated Deportivo Alavés 3–0 in their last match before the international break, with Lewandowski scoring his first hat-trick of the season.

[40] On 23 October, Barcelona defeated Bayern Munich 4–1 in a statement win and ended the six-match winless streak against the Germans.

[45][46] With this win Barcelona ended Real Madrid's 42-game unbeaten La Liga run and defended their record for the most consecutive league games without a loss in La Liga history, which stands at 43 matches, and went six points clear at the top of the league table.

Source: La Liga 1 Matchday 19 (vs Mallorca) was brought forward due to both clubs' involvement in the 2025 Supercopa de España.