[9] On 1 July, Inter bid farewell to Juan Cuadrado, Davy Klaassen, Alexis Sánchez, and Stefano Sensi as their contracts expired.

[23] On the same day, an own goal from Berat Djimsiti, a volley from Barella, and a brace from Thuram helped Inter secure a 4–0 victory over Atalanta before the international break.

[24] On 15 September, a heavily rotated Inter squad struggled against Monza, with Denzel Dumfries scoring a late equaliser to salvage a 1–1 draw.

[27] On 22 September, Inter suffered their first defeat of the season, losing 1–2 to AC Milan in the Derby della Madonnina, ending a six-game winning streak against their city rivals.

Federico Dimarco initially equalised after Christian Pulisic’s opening goal, but Matteo Gabbia’s 89th-minute header secured the win for the Rossoneri.

[31] After the second international break, on 20 October, Inter secured a 1–0 victory against Roma at the Stadio Olimpico, with Lautaro scoring the only goal of the match.

[32] Three days later, in the Champions League, the Nerazzurri struggled away at Swiss side Young Boys but earned a 1–0 victory thanks to a last-minute goal from Thuram.

[42] This marked Inter's fifth consecutive clean sheet in the Champions League across their first five matches, a feat only previously achieved by Juventus in 2004–05 and Manchester United in 2010–11.

[47] On 16 December, Inter returned to winning ways with a dominant 6–0 victory over Lazio, thanks to goals from Çalhanoğlu, Dimarco, Barella, Dumfries, Carlos Augusto, and Thuram.

[52] However, four days later, in the final against city rivals AC Milan, Inter squandered a 2–0 lead, courtesy of goals from Lautaro and Taremi, as the Rossoneri mounted a dramatic 3–2 comeback to claim the first trophy of the season.

[57] In the Champions League, on 22 January, Inter secured a 1–0 away win against Czech side Sparta Prague, with Lautaro scoring the only goal of the match.

[58] Then, on 29 January, Lautaro netted a hat-trick to give Inter a commanding 3–0 victory over Monaco, ensuring they finished fourth in the league phase and advanced directly to the round of 16.

[60] The following day, Zalewski made his debut and provided the assist for Stefan de Vrij's last-minute equaliser in the Derby della Madonnina, which ended in a 1–1 draw.

[61] On 6 February, Inter suffered a heavy 0–3 loss against Fiorentina in the rescheduled match originally set for 1 December, missing the opportunity to reach league leaders Napoli.

[62] Just four days later, however, Inter exacted their revenge, defeating the Tuscan side 2–1, thanks to an own goal by Marin Pongračić and a headed strike from Marko Arnautović.

[66] On 25 February, goals from Arnautović and Çalhanoğlu helped Inter secure a 2–0 victory over Lazio in the Coppa Italia quarter-finals, with the Nerazzurri set to face city rivals AC Milan in the two-legged semi-finals.