The 2024–25 LEN Champions League is the 62nd edition of the newly renamed European Aquatics's premier competition for men's water polo clubs.

The team that finish third and fourth will compete in the 2024–25 LEN Euro Cup knockout stage.

The remaining eight teams in the quarter-finals round will play a further six matches, with the top two in each group making the final four.

In this season, as FTC-Telekom are the reigning champions, Hungary's spot was given to the Hungarian runners-up, A-Híd Vasas Plaket.

[7] Croatia also saw a team withdrawing with Primorje EB Rijeka, who placed third, giving up their spot.

AN Brescia Jug AO Dubrovnik (H) NC Vouliagmeni Astrapool Sabadell (H) Spandau 04 CC Ortigia CN Barcelona Radnički Kragujevac (H) VK Šabac Jadran Herceg Novi CSM Oradea (H) HAVK Mladost Zagreb BVSC-Zugló Enka Istanbul Pays d'Aix Natation VK Banja Luka Dinamo București

Of the teams who progressed from qualification, Radnički Kragujevac and CSM Oradea return after being absent for three and eleven years respectively.

On 18 January 2024, the final four was held in the capital of Malta, Valletta, at the National Pool Complex.