The 2024–25 Malian Première Division is the 58th season of the highest level of professional football in Mali.
The winners qualify for the 2025–26 CAF Champions League.
The bottom Two teams are relegated to the 2025–26 Malian Division 1.
The league consisted of fourteen teams; the top twelve teams from the previous season, and two teams promoted from Malian Division 1 (Étoiles Mandé and FC Diarra, replacing USC Kita,ATS Koro,CO Bamako and Black Stars).
[1] Djoliba AC entered the season as defending champions.