[4] In March, they announced another game in the United States – against Real Betis on 31 July at Snapdragon Stadium in San Diego, a venue with which the club shares a sponsor.

[5] Ten days later, United announced they would play Rangers for the first time in a decade at Murrayfield Stadium in Edinburgh on 20 July.

[6] The first match of their pre-season tour was announced on 5 April; they faced Norwegian side Rosenborg at Lerkendal Stadion in Trondheim on 15 July.

[8] They registered their first win of pre-season in Scotland, where they beat Rangers 2–0 thanks to goals from Amad Diallo and Joe Hugill; newly signed defender Leny Yoro made his debut in the game, playing the first 45 minutes.

[9] In the first game of the U.S. tour against Arsenal, Rasmus Højlund put United ahead early; however, both he and Yoro suffered injuries in the first half that ruled them out of the opening matches of the season.

[13] After United took the lead late in the second-half through Alejandro Garnacho, City equalised through Bernardo Silva in the 88th minute, taking the game to penalties.

André Onana saved City's first penalty from Silva, but Jadon Sancho's miss with United's fourth kick meant the shoot-out went to sudden death; Jonny Evans put United's eighth penalty over the bar, allowing Manuel Akanji to give City a 7–6 victory.

João Pedro then scored a late winner with an unmarked header at the backpost, condemning the Red Devils to a first league defeat of the season.

United's next game against Crystal Palace was a 0–0 draw, where Onana gained his third clean sheet of the season after being forced into a double-save that later won Premier League Save of the Month for September.

To close the month, the Red Devils hosted Tottenham Hotspur, and they conceded in the third minute after centre-back Micky van de Ven was allowed to run through the midfield unchallenged before setting up Brennan Johnson to score.

Bruno Fernandes was sent off for the first time in his career after a late tackle on James Maddison, leaving United with 10 men just before half-time.

An exemplary performance from defender Jonny Evans helped secure a clean sheet, though Villa's keeper and Man of the Match Emiliano Martínez held United to a goalless draw.

The visitors opened the scoring when Ethan Pinnock headed in a corner in the fifth minute of stoppage time at the end of the first half.

United opened the scoring in the second half, with Rasmus Højlund being taken down in the box by Chelsea goalkeeper Robert Sánchez with Bruno Fernandes subsequently converting the penalty.

[22] United then hosted Leicester City and opened the scoring in the 17th minute through a Bruno Fernandes shot at the edge of the box into the bottom right corner.

[23] United's first game under newly appointed head coach Ruben Amorim came after another international break and saw them travel to Ipswich Town.

Rasmus Højlund was able to equalise in the 18th minute, scoring a rebound after Garnacho had his shot saved by Forest goalkeeper Matz Sels.

In the 61st minute, Bruno Fernandes scored a goal from the edge of the box, but United were unable to convert any of their other chances, and the game finished 3–2.

Just two minutes after the penalty, Antoine Semenyo scored the final goal and United lost 3–0 at home to Bournemouth for the second season in a row.