Ahead of the season, manager Marc Skinner signed a one-year contract extension.

[3] A third match, against WSL debutants Crystal Palace on 16 February 2025, was initially scheduled to take place at Old Trafford, but was later moved to Leigh Sports Village instead.

[3][4] Amid disruptions caused by ongoing redevelopment work to the men's first-team facilities at United's Carrington training base,[5] the club confirmed United Women would spend multiple weeks of pre-season based at St George's Park in Burton upon Trent.

[9] As a member of the first tier, United entered the FA Cup in the fourth round proper.

The draw for the knockout phase was made on 16 December 2024, with United being drawn at home against Manchester City in the quarter-finals.