The 2024–25 Quaid-e-Azam Trophy was a first-class domestic cricket competition held in Pakistan during the 2024–25 season from 26 October to 6 January 2025.

It was the 68th edition of the Quaid-e-Azam Trophy, and it is contested by 18 teams representing regional cricket associations.

Three of the teams – Larkana Region, Azad Jammu & Kashmir Region and Dera Murad Jamali Region – were competing at first-class level for the first time.

[2] After a 15-match round-robin in each pool, the top team from each pool took part in a three-team, three-match series.

The top two teams from this series then played off in the final, beginning on 2 January.