The competition started on 7 August 2024 and was scheduled to pause for a winter intermission on 27 October after Round 12 but was extended due to Russian hostilities of the ongoing Russo-Ukrainian War.

The last 6 rounds of the competition were scheduled to be played in the following spring.

[1] On 29 October 2024, the PFL announced that during the winter break on initiative of separate clubs from the Second League it is organizing an invitational friendly tournament starting 2 November 2024 and finishing around 30 November 2024.

[2] One team of the 2021–22 Ukrainian First League was readmitted to professional competitions: Four teams have been promoted from the 2023–24 Ukrainian Football Amateur League: Eight second teams have been added: Two teams were relegated from the 2023–24 Ukrainian First League.

Additional notes: Notes: As of 6 November 2024[update][30] Notes: The winner of the league's title play-off gains direct promotion to the 2025–26 Ukrainian First League.