The 2024–25 Virginia Tech Hokies women's basketball team will represent Virginia Polytechnic Institute and State University during the 2024–25 NCAA Division I women's basketball season.

The Hokies will be led by first-year head coach Megan Duffy and will play their home games at Cassell Coliseum in Blacksburg, Virginia as members of the Atlantic Coast Conference.

Duffy will enter her first season after being hired to replace Kenny Brooks on April 3, 2024.

As the first seed in the ACC tournament, they earned a bye into the Quarterfinals where they defeated ninth seed Miami before losing to eventual champions Notre Dame.

After the loss, head coach Kenny Brooks announced that he was stepping down from the team in order to accept the head coaching position at Kentucky.