Along with competing in the URC and its Irish Shield competition, the club will also participate in the 2024-25 European Rugby Champions Cup, their 31st season of European and professional competition.

Pink background indicates teams that are in play-off places and earn a place in the 2025–26 European Challenge Cup Yellow background indicates the team that won the 2024–25 European Challenge Cup and thus qualify for the 2025–26 European Champions Cup, but are not in a play-off place Plain background indicates teams that earn a place in the 2025–26 European Challenge Cup.

H: home field advantage secured for quarter-and semi-final.

h; home field advantage secured for quarter-final X: cannot reach play-offs.

(S) : URC Shield champion Munster finished their European Rugby Champions Cup pool campaign as the ninth seed, and were therefore drawn away in the round of 16 to the eighth seed, La Rochelle.