[1] The winners of the 2024 CONCACAF Caribbean Cup qualified to the 2025 CONCACAF Champions Cup Round of 16, and the second and third place teams qualified to Round One.

[1] Ten teams from five CFU member associations qualified for the tournament.

Eight teams from four nations qualified based on results from their domestic leagues and the remaining two teams qualified from the 2024 CFU Club Shield.

The first and second-place finishers advanced to the knockout stage.

[3] The knockout stage was played on a single-elimination tournament with the following rules:[4] The winners and runners-up of each of the four groups in the group stage advanced to the quarter-finals.