The 49ers played their home games at Jerry Richardson Stadium in Charlotte, North Carolina, and competed in their second season as a member of the American Athletic Conference (AAC).

[2] On December 7 the 49ers announced the hiring of Colorado tight ends coach Tim Brewster for the same position at Charlotte.

John Morookian made an internal move from tight ends to offensive line.

Jason Barnes joined the coaching staff from the analyst pool to take over wide receivers.

[3] On January 8, North Carolina defensive analyst Ty Greenwood was named cornerbacks coach.