[9][10] On July 14, following a defeat to the Pittsburgh Pirates, the White Sox established a new MLB record for the highest number of losses before the All-Star break, totaling 71.

[15] Eight days later, on August 25, the White Sox became the fastest team since the 1916 Philadelphia Athletics to lose 100 games in a season when they lost to their division rival Detroit Tigers, dropping them to 31–100.

[9] With this loss, the White Sox had their first 0–10 homestand in franchise history and became the first team since the 1965 Mets to have three losing streaks of at least ten games.

[7][9] On September 27, the White Sox lost their 121st game of the season, losing to the Tigers, surpassing the 1962 Mets for the most losses in modern MLB history.

White Sox outfielder Andrew Benintendi acknowledged the fans' reaction after the game by saying: "People here tonight were trying to see history.

The Tigers' broke the deadlock in the bottom of the 5th inning, with Jake Rogers scoring from third base on a wild pitch thrown by Jared Shuster.

Matt Vierling hit a sacrifice fly two pitches later, scoring Parker Meadows to put Detroit up 2–0.

[42] The White Sox responded in the top of the 6th inning, with Zach DeLoach hit a 401-foot home run to right field, the first of his major league career, to cut the lead to 2–1.

The Tigers extended their lead in the bottom of the 7th, when Andy Ibáñez led off with a double to right-center and reached third base due to a fielding error by center fielder Dominic Fletcher.

Later in the inning, another wild pitch thrown by Fraser Ellard scored Vierling, pushing Detroit's lead to 4–1.

[42] Detroit relied entirely on their bullpen for pitching, with multiple relievers combining to effectively limit the White Sox to a single run.

[39] Several White Sox fans posted derogatory and sarcastic images and comments mocking the team for making history with their loss record following the game.