Veterinary technicians must have an associate's degree and can assist veterinarians and provide treatment for minor conditions.

Veterinary technician specialists must have an associate's degree in addition to at least three years of clinical training and can perform all of the responsibilities of a veterinary technician in addition to performing emergency medical and surgical assistance.

The new position of veterinary professional associate created by Proposition 129 requires a master's degree and is able to perform many tasks technicians specialists are not allowed to, such as routine surgeries.

The group All Pets Deserve Care circulated petitions, funded mostly by the Dumb Friends League.

[5] The state's official voter guide offered the arguments against the measure that the requirements layed out by Proposition 129 are vauge and unclear, there are currently no academic programs offered for veterinary professional associates in Colorado universities, and it would increase risk for animals.