On 11 February, Istiklol announced that Igor Cherevchenko and his coaching staff had all left the club after their contracts had expired.

[1] On 26 February, Istiklol confirmed that both Romish Jalilov and Shahrom Sulaymonov had left the club at the end of their contracts, and joined Khosilot Farkhor.

[14][15] On 2 July, Istiklol announced that their contracts with Kabir Salimshoev and Alidzhon Karomatullozoda had been terminated by mutual consent.

[22] On 3 August, Istiklol announced the signing of Matthew Millar who'd most recently played for Macarthur FC and Dimitar Mitkov from Lokomotiv 1929 Sofia both on a contracts until the end of the season.

[23][24] On 4 August, Istiklol announced the signing of Francesco Margiotta who'd most recently played for Botoșani, to a one-year contract.