Magdalena Fręch defeated Olivia Gadecki in the final, 7–6(7–5), 6–4 to win the singles tennis title at the 2024 Guadalajara Open.

It was her first WTA Tour title.

[1] Maria Sakkari was the reigning champion,[2] but withdrew before the start of the tournament.

The top four seeds received a bye into the second round.