The Texas Rangers were awarded the game on November 17, 2022 by Major League Baseball Commissioner Rob Manfred.

[2] The starting rosters for each league's position players plus designated hitter (DH) were determined by fan balloting, which was conducted in two phases.

Reserve position players and all pitchers—selected "via 'Player Ballot' choices and selections made by the Commissioner’s Office"—was announced on July 7.

[4] The leading vote getter in each league during phase one was Aaron Judge of the New York Yankees and Bryce Harper of the Philadelphia Phillies.

[6][7] The American League uniforms featured a sand base with coral red sleeves and light blue cuffs.

Then, Shohei Ohtani hit a three-run home run off pitcher Tanner Houck, leading off the National League at 3–0.

In the bottom half of the third inning, Juan Soto hit an RBI double to score Steven Kwan and Marcus Semien.

In the bottom of the fifth, Anthony Santander singled, then Jarren Duran hit the game winning two-run home run to give the American League their first lead at 5–3.