[8] In their fifth season in the league, Inter Miami CF won the Supporters' Shield for the first time, earning an league-record 74 points.

[9] The LA Galaxy won a record sixth MLS Cup, and a first since 2014, after defeating the New York Red Bulls 2–1 at Dignity Health Sports Park in Carson, California.

[13] The regular season consisted of 34 matches for each team, split evenly between home and away games.

Matches were paused from July 25 to August 23 for the 2024 Leagues Cup, a knockout tournament that included teams from MLS and Liga MX.

The league did not pause matches for the 2024 Copa América, which was played in the United States from June to July.

[39][41] Several new rules were scheduled to be introduced for the 2024 season following trials in MLS Next Pro, including in-stadium announcements of video assistant referee decisions, a time limit for substitutions, and mandatory off-field checks for injured players.

With the exception of the 2025 FIFA Club World Cup, MLS teams were allowed to compete in up to two extra tournaments for the 2025 campaign.