Olivia Gadecki and John Peers defeated Kimberly Birrell and John-Patrick Smith in the final, 3–6, 6–4, [10–6] to win the mixed doubles tennis title at the 2025 Australian Open.

They saved a match point en route to the title, in the quarterfinals against Zhang Shuai and Rohan Bopanna.

Gadecki and Peers became the first all-Australian team to win the title since Jarmila Wolfe and Matthew Ebden in 2013.

[2][3] Hsieh Su-wei and Jan Zieliński were the defending champions,[4] but lost in the second round to Irina Khromacheva and Jackson Withrow.

Desirae Krawczyk was vying to complete the Career Grand Slam in mixed doubles, but she and her partner Neal Skupski lost in the first round to Tímea Babos and Marcelo Arévalo.