The 2025 Jacksonville State Gamecocks football team will represent Jacksonville State University in Conference USA (C-USA) during the 2025 NCAA Division I FBS football season.

The Gamecocks are expected to be led by Charles Kelly in his first year as the head coach.

[1] The Gamecocks play home games at Burgess–Snow Field at JSU Stadium, located in Jacksonville, Alabama.

[2][3][4] [14] at FBC Mortgage Stadium • Orlando, FL at Burgess–Snow Field at JSU Stadium • Jacksonville, AL at Paulson Stadium • Statesboro, GA at Burgess–Snow Field at JSU Stadium • Jacksonville, AL at M. M. Roberts Stadium • Hattiesburg, MS at Bowers Stadium • Huntsville, TX at Burgess–Snow Field at JSU Stadium • Jacksonville, AL at Johnny "Red" Floyd Stadium • Murfreesboro, TN at Sun Bowl • El Paso, TX at Burgess–Snow Field at JSU Stadium • Jacksonville, AL at Bowers Stadium • Miami, FL at Burgess–Snow Field at JSU Stadium • Jacksonville, AL