Santiago, Isabela voters will elect a mayor, a vice mayor, and 10 out of 13 councilors of the Santiago City Council.

Incumbent Sheena Tan (Lakas–CMD) is running for a second term.

The following candidates are included in the ballot:[1][2] Incumbent Jojo Vaquilar (Partido Federal ng Pilipinas) for a third term unopposed.

The following candidates are included in the ballot:[1][2] The Santiago City Council is composed of 13 councilors, 10 of whom are elected.

The following councilors are retiring: The following board members are term-limited: The following candidates are included in the ballot:[1]