The 2025 UEFA European Under-21 Championship qualification is a men's under-21 national football team competition to determine the 15 teams that will be joining the automatically qualified hosts Slovakia in the 2025 UEFA European Under-21 Championship final tournament.

Apart from Slovakia, Liechtenstein (dissolved their U21 team until 2025) and Russia (banned due to the ongoing invasion of Ukraine), all remaining 52 UEFA member national teams entered this qualifying competition.

Based on the decisions taken by the UEFA Emergency Panel, the following teams would not be drawn in the same group.

As a result, eight matches played by each second-placed team are counted for the purposes of determining the ranking.

The draw for the play-offs was held on 17 October 2024 in Nyon, Switzerland.