The 2025 Vuelta a Murcia was the 45th edition of the Vuelta a Murcia road cycling race.

It was held on 15 February 2025 in the titular region of southeastern Spain as a category 1.1 event on the 2025 UCI Europe Tour calendar.

Five UCI WorldTeams, nine UCI ProTeams, three UCI Continental and one national team made up the eighteen teams that participated in the race.

[1] UCI WorldTeams UCI ProTeams UCI Continental Teams National Teams