Ahead of the 2024 NRL Grand Final, reports began circulating that the 2025 World Club Challenge would be at risk of being cancelled as teams that could potentially qualify (Penrith Panthers, Warrington Wolves, and Wigan Warriors) would have difficulty arranging travel to either the UK or Australia, then to the United States, with the usual date of the tournament being close to that of the 2025 Rugby League Las Vegas event.

The club stated that it was open to working with the NRL for a solution to play the match, but would not as things stand currently.

[10][11] Wigan remain world champions by virtue of their victory in the competition in 2024, however did not receive a separate title for 2025 in lieu of Penrith's withdrawal.

On 9 July 2024, the club announced they would be part of the 2025 Rugby League Las Vegas event, playing their home match against Warrington Wolves at the Allegiant Stadium in Paradise, Nevada.

[12][13] Wigan's matchweek 1, 2, and rival Round fixtures were confirmed on 20 November 2024,[14] with the rest coming the following day.