The 2028 United States Senate elections will be held on November 7, 2028, with 34 of the 100 seats in the Senate being contested in regular elections, the winners of which will serve 6-year terms in the United States Congress from January 3, 2029, to January 3, 2035.

If vacancies occur in Class 1 or Class 2 Senate seats, that state might require a special election to take place during the 120th Congress, possibly concurrently with the other 2028 Senate elections.

They are arranged so that the parties are separated and a majority is clear by crossing the middle.

[2] One-term Democrat Mark Kelly was elected to a full term in 2022 with 51.4% of the vote after winning a special election in 2020 to complete the remainder of Republican John McCain's term.

[4] One-term Democrat Alex Padilla was elected to a first full term in 2022 with 61.1% of the vote, having first been appointed in 2021 to complete the remainder of Democrat Kamala Harris's term upon her swearing in as Vice President of the United States under the Biden administration.

Governor Ron DeSantis announced he would appoint Florida Attorney General Ashley Moody as an interim successor to serve until the vacancy is filled by a special election in 2026.

[8] Democratic incumbent Brian Schatz was re-elected in 2022 to a second full term with 71.2% of the vote.

[10] The most senior member of the Senate, Grassley will be 95 years old at the time of the election.

Two-term Republican John Kennedy was re-elected in 2022 with 61.6% of the vote in the first round of the "Louisiana primary".

The election to this seat will be the first under a new law which abolished the state's open primary system.

[11] Two-term Democrat Chris Van Hollen was re-elected in 2022 with 65.8% of the vote.

Two-term Democrat Catherine Cortez Masto was re-elected in 2022 with 48.8% of the vote.

However, he resigned on January 10, 2025, shortly before assuming the office of vice president under the current second Trump administration.

[18][19] Names circulated on Vance replacements include 2024 Senate candidate and state senator Matt Dolan, and Ohio Secretary of State Frank LaRose.

On January 29, 2024, the Oklahoma Republican Party censured Lankford for negotiating with Democrats on a potential border deal.

[24] In an interview the following month, former president Donald Trump stated that Lankford's actions are "very bad for his career" and did not rule out endorsing a primary challenger in 2028.