Mrs. Walter McNab Miller served as President for an original group of 84 women.

In 1894, Club members started a circulating library, and in 1898 a scholarship to the University of Nevada was funded.

Much social life of Reno revolved around the facilities of this Clubhouse – weddings, luncheons, dinner dances, and civic meetings.

Before 1930, the 20th Century Club was involved in a wide variety of causes like passing laws that prohibit spitting on sidewalks, social causes, education and morale.

The building was designed by Fred M. Schadler and includes Classical Revival and Prairie School architecture.