2120 South Michigan Ave. is the fifteenth studio album by George Thorogood and the Destroyers.

[1] Buddy Guy and Charlie Musselwhite perform on the album,[7] although their work was added after primary recording was complete.

[5][10][11] 2120 South Michigan Ave. received positive reviews from critics.AllMusic's Stephen Thomas Erlewine wrote "George Thorogood & the Destroyers have never made their debt to Chess Records a secret, so an album-length tribute to the home of Muddy Waters, Howlin’ Wolf, Willie Dixon, Chuck Berry, and Bo Diddley is a logical move for the rough and tumble blues-rockers.

"[8] Daily Vault's Christopher Thelen says "2120 South Michigan Avenue will be a treat to not only that fanbase, but to students of classic blues music – and, if the listener learns something while enjoying this disc, all the better.

"[17] William Pinfold of Record Collector wrote "That said, from the slightly cheesy influence-referencing Going Back to the final Stones cover, it’s a wholly enjoyable album with heart and soul to spare.