The 215th Regiment Pennsylvania Volunteer Infantry (9th Union League) was an infantry regiment of the Union Army in the American Civil War.

It was raised in Philadelphia close to the end of the war, and spent most of its slightly more than three months of service guarding Confederate prisoners while garrisoning Fort Delaware.

The 1,117-strong 215th Pennsylvania Infantry was organized at Camp Cadwalader on 21 April 1865, with men from Philadelphia and the counties of Lancaster, Bucks, and Northampton, under the command of Regular Army officer Colonel Francis Wister, the last Pennsylvania regiment raised for the war.

[1] Though most of the regiment was from Philadelphia, Company G was recruited at Easton in Northampton County.

[5][6] During its service, eleven men of the regiment died of disease.