The film stars Hill and Channing Tatum in the lead roles alongside Brie Larson, Dave Franco, Rob Riggle and Ice Cube.

In the film, police officers Schmidt and Jenko are forced to relive high school when they are assigned to prevent the outbreak of a new synthetic drug and arrest the supplier.

A sequel, 22 Jump Street, was released on June 13, 2014, and in 2015 a female-led spin-off was in development with main stars cast in 2018 and the first draft completed in 2020.

They catch a break when they arrest Domingo, the leader of a one-percenter motorcycle gang, but are forced to release him after they fail to read him his Miranda rights.

Captain Dickson assigns them to contain the spread of a synthetic drug called HFS ("Holy Fucking Shit") at Sagan High School.

Schmidt gets a lead on HFS from classmate Molly, and he and Jenko meet the school's main dealer, popular student Eric.

Jenko becomes friends with the students in his AP Chemistry class and finds himself becoming more interested in geeky hobbies and academic pursuits.

Schmidt and Jenko later track Eric to a cash transaction with the distributors of HFS—the motorcycle gang from the park—and a chase ensues on the freeway.

Eric, stressed and terrified, recruits Schmidt and Jenko as security for a deal taking place at the school prom.

The motorcycle gang arrives for the deal, but Molly, high on the HFS, interrupts them and starts arguing with Schmidt.

As a result, gang leader Domingo recognizes Schmidt and Jenko and orders his men to kill them.

Mr. Walters and Eric escape with the money and Molly as a hostage; the gang, Schmidt, and Jenko follow close behind.

Both officers are congratulated and reinstated in the Jump Street program as Dickson gives them a new assignment: infiltrating a college.

The songs featured in the film include: The premiere of 21 Jump Street took place on March 12, 2012, at the Paramount Theatre in Austin, Texas, during SXSW.

The site's critical consensus reads, "A smart, affectionate satire of '80s nostalgia and teen movie tropes, 21 Jump Street offers rowdy mainstream comedy with a surprisingly satisfying bite.

[27] Richard Roeper of The Chicago-Sun Times gave the film a grade of a B+ saying, "I didn't think we needed a 21 Jump Street, but it's actually kind of funny.

We begin in medias res, and within ten pages establish (in a single shot) [...] all the conflict, interpersonal and personal [...] I groaned when I heard Tatum and Hill had been cast as the lead, but they proved to be a great double-act who did justice to the script's nutty humour.

The news was leaked after Sony's system was hacked[44] and then confirmed by the directors of the films, Chris Miller and Phil Lord, during an interview about it.

[52] By November 2020, it was revealed that Wendy Molyneux and Lizzie Molyneux-Logelin had completed a draft of the script, while the official title was announced to be Jump Street: Now for Her Pleasure.

[53] In July 2023, a spin-off Jump Street film featuring Molly Tracey was announced to be in development.