[2] The 222nd Mixed Brigade was established in the summer 1937 in Lorca, Vélez-Rubio, Alhama and Totana.

The brigade was first engaged in Coastal Defence under the Group of Central Region Armies (GERC) and its members were garrisoned in Cartagena, guarding the town's military facilities.

[2] The brigade took part in the effort to fight back the rebel Levante Offensive where it recaptured the Cota 1.196 and the Vértice Marrón positions from the enemy.

For these actions the 40th Division, to which the brigade belonged, was awarded the Medal of Bravery.

[2] In July 1938 the 40th Division was placed under the XVII Army Corps led by Lieutenant Colonel García Vallejo.