22nd Street station is a Caltrain commuter rail station located south of 22nd Street between the Dogpatch and Potrero Hill neighborhoods of San Francisco, California beneath the Interstate 280 freeway viaduct.

The only below-grade Caltrain station, it is bracketed on the north and south by two tunnels which take the line under the eastern slope of Potrero Hill.

[3] The station opened when the Southern Pacific Railroad built the Bayshore Cutoff in 1907.

[5] A December 2021 study recommended the installation of ramps as an interim accessibility measure pending future reconstruction or relocation.

[7] Under the Pennsylvania Avenue alternative of the Downtown Rail Extension (now known as The Portal) project, Caltrain tracks would be placed in a new tunnel north of 22nd Street.