The 28th Annual Screen Actors Guild Awards, honoring the best achievements in film and television performances for the year 2021, was presented on February 27, 2022 at the Barker Hangar in Santa Monica, California.

The nominees were announced on January 12, 2022 by Rosario Dawson and Vanessa Hudgens via Instagram Live.

[7] For her performance as Anita in Steven Spielberg's West Side Story, Ariana DeBose became the first Afro-Latina and openly queer woman of color to win the Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Supporting Role.

Helen Mirren was announced as the 2021 SAG Life Achievement Award recipient on November 18, 2021.

[8] The segment, introduced by Maggie Gyllenhaal, was set to the song "Sailboat" by Cody Fry and Ben Rector, and honored the following who died in 2021 and early 2022:[9][10]